After I saw that movie, I had a dream that David Lynch explained it to me, and I STILL didn't get it!
Here's a go at a Wayne Higgins spoiler: Young girl goes to Los Angles looking for fame and meets Lucifer and Abbaddon (disguised as old Jewish couple). When she finally gets her chance for a big break, she is passed over by a group of Mafia men with a peculiar way of drinking expresso. She ends up a diner with her newly found lesbian lover, but they won't let her eat.
I do think that David Lynch believes that Hollywood is the gateway to hell.
My spoiler for "Lost Highway" is better. Man in jail for murdering his wife sells his soul to the devil so that he can go bowling. "Dune": read the book, but just skim over the last 372 pages. "Blue Velvet": Jeff goes home from college to North Carolina and hangs out with some interesting locals. "Wild at Heart": Elvis Presley meets Glenda, so hot that it is guarenteed to make you stop the movie and have sex. "The Straight Story": old man rides a tractor. "Eraserhead": the perils of a bad hair day. "Elephant Man": best movie ever made about the elephant man. "Twin Peaks: Fire Walk With Me": my personal favorite. An attempt to explain why a tv series was made, but no log lady. Includes great shots of Moria Kelly, Sheryl Lee and Phobe Augustine in a bar scene which is not to be missed.
I love David Lynch movies.