Just my sixpence worth on the subject. I found Samplitude 11 Pro to be the one that suits me best. It was a little pricey to buy it at first, but in the long run proved to be fantastic value for money. I use Samplitude for all audio work (guitars, drums, bass, strings etc.) and Sonar X1 for all MIDI tasks (synths, ethnic libraries etc). It's a long-winded way of working but it gets me the results I want. Can't see myself changing from the formula unless someone gets bought out or the companies go bust.