I am not a huge fan of soft-synths, but then again I do like them
Meaning I think they are a lot of fun and I love the ease of programing them, but I am not a fan of albums that are soft synth only so to speak.
Having said that I do own the entire NI Komplete, but the only synths I use out of it consistently are FM-8 and Kontakt (a sampler I know) and Kontakt is usually for organ and piano sounds and such when a client needs them in a pop mix.
The ones that show up regularly in my work are FM-8 and the Korg Wavestation and M-1. I guess what I am comfortable with are emulations of hardware synths I used to own and are digital synthesis in nature and not analog emulations. I also am a huge fan of physical modeling and I have been loving the new Chromophone by AAS.
Honorable mention goes to NI's Massive, AAS Tassman and G-Force Oddity as well.
I am however curious to upgrade to Cubase 6.5 as I have heard great things about their new padstation and a new ana-emo that come in the new version.