I'd say there's a big difference between binaural recordings and 'binaural plugins', which mostly appear to be some kind of HRTF (head related transfer functions) placement arrangements. Nothing wrong with that, I think they can be very interesting, using 'space' as a compositional consideration in a mix.
You don't lose information with the recording binaural technique, it's just a different way of capturing spatial information. I've found using a binaural recording of something like rain or a storm for example, gives a great spatial element to a track. Binaural recordings I'd say are
perhaps more suited to field recordings. If you (or anyone else) is interested in hearing an album of material derived from binaural recordings. I've made my 'Binaural Soundtracks' album a free download:
(Dropbox link 67.9 MB zip file)
Well I guess it depends on how you record, do you record with microphone or synth.
If you use electronic sounds these plugins can be very good to create dimensional space...
in my opinion it works in both speakers and headphones.. but as always spatial effects sounds best in headphones usually.
Problem number 1 is, the number of good sounding plugins that do this kind of stuff is very limited, in fact I only know one software that I would consider to buy and find actually useful. But I am not sure if I am able to control it with midi, maybe it is possible nowdays, if it is now..I am very eager to buy it.. I tried the demo some years ago, and I did get very good and interesting results with it. While using it I did find I got superior dimensional sound.