I enjoyed that video. A little bit. He's making some good points, but not connecting them in a way that I find useful.
1. No one cares. He's right. No one cares about your photographs. No one cares about your music. No one cares about your writing. No one cares about your art.
Granted, some artists are capable of attracting a sizable fan base. But, even in those cases, I think a lot of followers are just bandwagon fans. Very few people will be able to connect in a deep emotional way to anything you produce.
Once an artist fully appreciates that, I think it can be a source of liberty rather than a source of despair.
2. Do work that is meaningful.
Sure. I think everyone strives to do that. The problem is that he is suggesting this as a means to make people care about your work. I think that is a mistake.
I have an Ayn Rand way of thinking about art: The most important critic is yourself, and an artist must always be accountable to that critic.
If you're trying to make a living off your art, of course, then you have to appease others. And that is where the gray lines emerge.
But, outside of commerce, the goal should never be to create art that others will care about. It should always be about creating art that you care about. And one of the joys in life is finding those connections--meeting people who resonate with your art--whether it is visual, aural, or writing--in the way that you do. But that is a bonus; it isn't the endgame.